Adverse Reactions

In clinical trials, disadvantageous events most commonly noticed linked to the fluvoxamine administration and not seen in an equivalent impact among the patients treated as the placebo, were complaints gastrointestinal, by including nausea (sometimes accompanied by vomiting), constipation, anorexia, diarrhoeia and dyspepsia; the complaints of CNS, by including drowsiness, dry mouth, nervousness, insomnia, vertigo, shaking and agitation; and asthenia. Abnormal (especially postponed) the éjaculation was often announced by the patients with maniacal compulsive riot, principally in doses more than 150 mgs / days.

In a swimming pool of two studies implicating patients only with OCD, following additional events were identified: mouth dries, weak libido, urinary frequency, anorgasmia, rhinitis and the tasteful perversion.

Physical / psychological Dependency:
The potential for abuse, tolerance and physical dependency with fluvoxamine maleate was studied in a model of nonhuman primates. No obviousness of phenomena of dependency was found.

Generally, he is not possible to predict on the basis of pre-clinical clinical experience or précommercialisante measure in which an active medicament CNS will be fooled, diverted, and/or once commercialised. As a result, the doctors should assess patients carefully for a history of drug dependency and to follow such patients nearly, by noticing them for the signs of fluvoxamine maleate bad usage or abuse (that is to say, the development of tolerance, the incrimination of dose, behaviour searching the medicament).